Why Is Anaphase The Shortest Phase Of Mitosis

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You watching: Why is anaphase the shortest phase of mitosis

StatPearls . Treasure Island (FL): StatPearls Publishing; 2021 Jan-.


Genetics, Mitosis

Ibraheem Rehman; Aaishwariya Gulani; Mustafa Farooq; Brittany type of Simpchild.

Author Information


The capacity to recreate is one trait that sets living organisms apart from nonliving issue. The flow of life is based upon cell division or the reproduction of cells. Cell department deserve to play a various role in various organisms. For instance, as soon as a prokaryotic cell mostly divides, it has totally redeveloped bereason it offers climb to a new organism. However, in multicellular eukaryotes, mitotic cell division is largely provided for expansion and also replacement or repair of injured cells. Most cell department outcomes in genetically the same daughter cells.  First, a dividing cell replicates its DNA. After a range of measures, the cell divides using motisis and also cytokinesis. Mitosis is one part of the cell cycle, which is thorough listed below. <1><2><3>


The whole of a cell’s DNA is referred to as its genome. During cell division, the totality genome is replicated precisely and dispersed to 2 daughter cells. A huguy cell typically has around 2 meters of DNA. Due to the enormous length, the DNA should be very condensed to fit right into the nucleus of each cell. The very condensed packeras of DNA are termed chromosomes as soon as the cell has completed the synthesis phase and is ready to undergo mitosis. Various proteins aid the DNA in folding compactly right into subdevices of nucleosomes and chromatin. Person somatic cells have 2 sets of 23 chromosomes for a full of 46 chromosomes - 22 sets of autosomes and also 1 set of sex chromosomes. A single collection of chromsomes is inherited from each parent.<4><5><6> DNA packaging is debated in a different StatPearls reviews - Genetics, DNA Packaging and also Genetics, Hirock Code.


The mitotic phase is normally the shortest component of any cell cycle. The biggest percentage of the cell cycle, interphase, renders up 90% of a cell"s life cycle, and also is the phase for prospering and percreating the cellular features certain to that cell. The interphase is even more divided into two G phases- G1 and G2- and also an S phase. During these phases, the cell grows by creating miscellaneous proteins and cytoplasmic organelles. During the S phase, the cell replicates its genome in preparation for cell division or mitosis. Mitosis occurs during M phase, which occurs after interphase. <7>


Mitosis is conventionally split into 5 phases, which incorporate prophase, prometaphase, metaphase, anaphase and also telophase and cytokinesis. In interphase, a nuclear envelope surrounds the nucleus, the DNA is replicated in the S phase, and also the sister chromatids join together at the central portion of the chromosome - the centromere. To organize the chromsome motion in the cell to aid make department effective as well as ensure all product is current in both daughter cells, the cell has actually centrosomes at each pole of the cell. Centrosomes organize the fibers of the mitotic spindle in the time of mitosis that will aid pull the sister chromatids apart.

In prophase, the chromatin fibers condense right into chromosomes that are visible through a light microscopic lense, each replicated chromosome shows up as two identical sister chromatids joined at their centromeres, and the mitotic spindle starts to create. Also, the centrosomes start to move to oppowebsite poles of the cell, and also they are driven by the lengthening microtubules in between them.

In prometaphase, the nuclear envelope falls apart; microtubules deserve to now attack the nuclear area and bind to some of the chromosomes. The microtubules bind at the kinetochores, specialized protein structures at the centromere. Not all microtubules interact through kinetochores. Some microtubules interact through microtubules extending from the various other side of the cell.

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In metaphase, the centrosomes have moved to opposite poles of the cell. The chromosomes have actually all lined up at the metaphase plate in the middle of the cell, and also all chromosomes are attached to microtubules via their kinetochores. The metaphase plate is an imaginary line equifar-off from the spindle’s 2 poles.

In anaphase, the shortest phase of mitosis, the sister chromatids break acomponent, and the chromosomes begin relocating to opposite ends of the cell. By the finish of anaphase, the 2 halves of the cell have an indistinguishable collection of chromosomes.

In telophase, 2 daughter nuclei develop. The nuclear envelope beings to reshow up. DNA starts to de-condense while spindle microtubules start to depolymerize. Mitosis, the department of one nucleus into 2, is currently complete. Lastly, cytokinesis, which is the division of the cytoplasm, takes area and the cell divides right into 2 separate cells. In pet cells, this is achieved through a cleavage furrow that pinches the cell in 2.


Throughout mitosis, particular checkpoints are essential to the continuation of the process. If particular problems are not met, mitosis halts. If any of these checkpoints are bypassed without being complete, specific pathology, such as cancer, can occur.<8><9>

Tright here are 3 primary checkpoints in mitosis, and also those include the G1/S checkpoint, G2/M, and metaphase/ anaphase checkallude. Throughout the G1/S checkallude, additionally well-known as the restriction checkpoint, primary influencers of cell cycle development encompass expansion components, DNA damages, cell size, and also cell nutrition.  The G2/M checkpoint, likewise known as the DNA replication checkallude, is affected by imappropriate DNA replication or DNA damage. The 3rd checkallude, also recognized as the spindle apparatus checksuggest, is inflienced by attachment of the mitotic spindle to all chromosomes. Only when all sister chromatids have been bound will certainly mitosis continue right into anaphase.<10>

Cell Types 

It is necessary to identify that cells can progression via the cell cycle in different manners. Cells can withattract from the energetic cell cycle, and also exist in a non-proliferating or quiescent state. These cells are sassist to be in the G0 phase. Throughout G1, a cells decide to reprimary in G1 or leave the active cell cycle and also enter right into the G0 phase. Different cell forms are classified below on their characteristic cell cycle progressions. <11>

Labile cell forms are cells that are constantly proliferating, via stem cells, in order to replace cells that have actually died or sloughed off. Some examples of labile cell kinds incorporate skin epithelium, gastrointestinal epithelium, salidiffer gland tproblem, and also hematopoietic cell forms. It is vital to identify that chemotreatment provided in cancer treaments has toxic results versus healthy cells, especially cells undergoind quick renewal.<12>

Quiescent or stable cell forms are usually in a non- dividing state, yet may enter the cell cycle  in respons to particular stimuli. Instances of steady cell types include: lymphocytes, hepatocytes, endothelial cells, and also others. 

Finally, permanent cell forms are unable to prolifeprice, and are taken into consideration non- dividing. Instances of irreversible cell kinds encompass cardiac and skeletal muscle. <13>